This isn't really a storyline, but I hate the opening song. I like the opening from season 1 much better.
I totally agree that season four was really bad. Painfully bad. But the one story line that I am still mad about is Breast Cancer and killing off Dana. First of all the story line could have been drawn out and developed in a more realistic portrayal of a breast cancer patient. I dont think that four episodes is long enough for fans to really come to terms with the whole cancer trauma and death all at once. Second, why did they have to kill her off the show?
Dana was my favorite character so to me the worst storyline was when she died. I have seen that episode at least 5-6 tmes and I still boo hoo like I have lost a great friend.