I am currently on my itouch so I like to use twitter applications for it. I use twittilator pro for the itouch, and twitfox for my firefox browser. I like both.
I like twittilator and Tweetie on my iphone..although, twinkle is really awesome too! On my Laptop I use Power Twitter...really liking it a lot..has the "peek" feature which I really enjoy.
I use twitteriffic and Halo 3.1 on my iPhone and I've just discovered TweetDeck for my laptops. The fact that I need two apps on my mobile, leads me to the idea of building my own app, with all the features I need - just how difficult can it be? ;0)
I'm going to have to go with Twitbin for Firefox ( http://www.twitbin.com/ )-- I complained about a few features and they actually listened to my complaints and fixed a few of them (they're still working on others). How fab is that!
I have tweetdeck and I like it, but I find that for my usage habits twitterbar is often more convenient. It is a FireFox add-on though so it won't be of much use if you still browse with IE. Any die hard IE fans still out there?
I love the script with Firefox Grease Monkey and the Google live search of twitter thingy (I'm obviously a technology guru eh?). Essentially, I search google and the first set of results are from twitter. That comes in super handy!